Last Edited: June 25th 2019, 12:38:01 AM, Author: Anthony Russano, firstname.lastname@example.org Donate!
- Açai seed extract (ASE) is rich in catechin and polymeric pro-anthocyanidins.
Acai Seed Extract has been shown to induce endothelium dependent vasodilation (vasodilation is the widening and relaxation of blood vessels).
- Endothelium dependent vasodilation: Endothelial cells produce a number of substances, collectively termed endothelium-derived relaxing factor (EDRF), that promote local relaxation of vascular smooth muscle.
Disease / Symptom Treatment
- Acai Seed Extract's ability to induce endothelium dependent vasodilation may help treat hypertension, atherosclerosis, and heart failure.
Acai berries are a promising functional food for the management and prevention of obesity. Açai seed extract (ASE) has been evidenced as a potential regulator of body mass. Research suggests that even low doses of the compounds found in acai berries may have a protective role against body weight gain and consequently obesity development.
- Inclusion of acai berries in the diet significantly improved plasma and tissue markers of obesity.
- Phenolic compounds found in Acai Seed Extract prevent body mass gain and obesity and promote body weight reduction by altering the expression of the specific genes involved in adipogenesis thereby positively modulating the metabolic pathways responsble for the creation of new fat cells.
Study Type: Animal Study
Title: Antiadipogenic effects of açai seed extract on high fat diet-fed mice and 3T3-L1 adipocytes: A potential mechanism of action
Author(s): Patricia Leticia Trindade, Elaine dos Ramos Soares, Elisa Bernardes Monteiro, Ângela Castro Resende, Nathalia Moura-Nunes, Vanessa Souza-Mello, Danielly Cristiny Ferraz, Julio Beltrame Daleprane
Institution(s): Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil; Laboratory of Cardiovascular Pharmacology and Medicinal Plants, Department of Pharmacology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Department of Anatomy, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Publication: Life Sciences
Date: April 2019
Abstract: Body adiposity is an important risk factor for the development of chronic non-transmissible diseases. Studies on the process of adipogenesis have been extensively performed in vivo and in vitro models to describe the molecular and cellular bases of adipose tissue development and the effect of natural products in this process. The açai seed extract (ASE) has been evidenced as a potential regulator of body mass. In our work high-fat diet–fed mice treated with ASE (300 mg/Kg/d) (HFD-ASE) showed a lower adipose index (−32.63%, p < 0.001) than the high-fat diet–fed mice group (HFD) and the adipocytes from the HFD group were considerably enlarged (p < 0.001) compared to those in the control group (CG) and HFD-ASE group (+175% and +123%, respectively). We also evaluated the effects of ASE on the modulation of adipogenesis in 3T3-L1 cells. ASE exposure (25 and 100 μg/mL) led to a decrease of 26.6 (p < 0.05) in proliferation and also inhibited pre-adipocyte differentiation through the decreasing expression (p < 0.05) of transcription factors and adipogenic proteins such as PPARɣ, SREBP-1, and FAS. These results show that the ASE reduce adipogenesis and suppress lipid accumulation in the in vivo model and in 3T3-L1 adipocytes and reinforce ASE as a potential strategy to modulate adipogenesis.
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