Author: Anthony Russano (Last Updated March 25th 2019, 11:26:23 PM)

Alpinia oxyphylla is a herbaceous plant that produces the "Yi Zhi Ren" fruit, also known as Black Cardamom or the "seed of wisdom".

Healing Properties

  • Antioxidant
  • Anti-T2DM (Prevents Type 2 diabetes mellitus)[1]
    • Modulates gut microbiota

Disease / Symptom Treatment

  • Dementia
  • Diabetes
    • Decreases urine albumin excretion.
    • Decreases resting blood sugar levels.
    • Improves glucose intolerance.
    • Decreases Glycated hemoglobin levels.
    • Promotes more efficient glycemic control.
    • Renal injury: Diabetic Induced Renal Injury can severely disrupt the architecture of the kidney, causing lesions and tubular atrophy.
      • 500 mg/kg of Alpinia Oxyphylla attenuated renal damage and nearly fully recovered kidney structure.[1]
  • Diarrhea
  • Inflammatory conditions


  1. Title: Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
    Author(s): Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, and Guankui Du
    Institution(s): First Affiliated Hospital of Hainan Medical University, Haikou 571199, China; Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, China
    Publication: Journal of Diabetes Research
    Date: 4 June 2018
    Abstract: Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H2O group. Compared with the db-/db-H2O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H2O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition.