The Aronia Berry (also known as the Chokeberry) is known for its dense content of polyphenols, especially anthocyanins. The total polyphenol and proanthocyanidin content are among the highest measured in plants to date.
Aronia Berries contain a high concentration of phenolic compounds (anthocyanins, procyanidins, hydroxycinnamic acids and flavonols).
The Aronia Berry has three varieties. Red chokeberry, Aronia arbutifolia (Photinia pyrifolia); Black chokeberry, Aronia melanocarpa (Photinia melanocarpa); and Purple chokeberry, Aronia prunifolia (Photinia floribunda).
- Anti-Diabetic activity: Oral administration of aronia 100 mg/kg has the effect of decreasing the increase of blood glucose level and also has the protection effect of pancreas β cells.
- Antiinflammatory: Aronia berry extract significantly suppresses inflammatory cytokines.
- Endothelial Health: Powerful inhibititor of vascular endothelial inflammation.
- Weight Loss: AJC supplementation has the potential to prevent weight gain and markers of obesity.
- Energy: Aronia Berry Juice Concentrate supplementation had a significant effect on diet efficiency causing subjects to need less energy intake to maintain body processes (i.e. growth) and become more efficient at using the energy they consume.
- Glucose Regulation: Aronia Berry Juice Concentrate supplementation has been shown to increase adiponectin levels.
- Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone which is involved in regulating glucose levels as well as fatty acid breakdown. In humans it is encoded by the ADIPOQ gene and it is produced in adipose tissue.
Disease / Symptom Treatment
- Type I Diabetes: Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia.
- Insulin Resistance: Aronia Berry decreased risk factors associated with insulin resistance in rats fed a fructose-rich diet through modulation of multiple pathways associated with insulin signaling, adipogenesis and inflammation.
- Inflammatory Bowel Disease: Aronia melanocarpa (Black Aronia Berry) fruit juice ameliorates the symptoms of inflammatory bowel disease.
- Colitis: The effects of taking Aronia Berry Juice were comparable or even higher than that of the Antiinflammatory drug sulfasalazine (works better than pharmaceutical drug).
- Obesity: Aronia Berry Juice Concentrate supplementation had a significant effect on preventing weight gain.
Title: The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro
Author(s): Jeon Yong-Deok, Kang Sa-Haeng, Moon Kwang-Hyun, Lee Jeong-Ho, Kim Dae-Geun, Kim Wook, Kim Jong-Sung, Ahn Byung-Yong, and Jin Jong-Sik
Institution(s): Department of Oriental Medicine Resources, Chonbuk National University, Iksan, South Korea; Department of Oriental Pharmacy, College of Pharmacy, Wongkwang-Oriental Medicine Research Institute, Wongkwang University, Iksan, South Korea
Publication: Journal of Medicinal Food
Date: 1 Mar 2018
Abstract: The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe. Aronia contains a variety of ingredients such as polyphenols, anthocyanins, flavonoids, and tannins. Especially, anthocyanin content in aronia berry is known to be much higher than in other plants and berries. It is known for exerting antioxidant, anti-inflammation, and Antiaging effects. Therefore, this study was conducted to investigate the effects of aronia berry extract intake in multiple low-dose streptozotocin (STZ)-induced T1D and to confirm the functional properties of aronia berry. ICR mice (6-week male) were divided into four groups: control (normal control group), STZ (100 mg/kg of STZ-induced T1D group), AR 10 (STZ with oral administration of aronia 10 mg/kg), and AR 100 (STZ with oral administration of aronia 100 mg/kg). Afterward, STZ was injected in a single dose to induce T1D, and the extract was orally administered daily. Dietary intake and body weight were measured twice a week. We confirmed that aronia berry has the effect of decreasing the increase of blood glucose level and also has the protection effect of pancreas β cell (RINm5F cell). This study confirms the anti-diabetic activity of aronia berry, and it can be expected to increase the utilization according to the results.
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Title: Polyphenol-rich Aronia Berry Extract Inhibits TNF-α-induced Vascular Endothelial Inflammation
Author(s): Tomomi Iwashima, Yuki Kudome, Emi Saita, Chie Taguchi, Yoshimi Kishimoto, Kaoruko Iida, Kazuo Kondo
Institution(s): Ochanomizu University, Tokyo, Japan; Toyo University, Gunma, Japan
Date: June 2018
Abstract: Objective: Vascular endothelial inflammation is well known to be an initial step in arteriosclerosis. Aronia berry (Aronia meranocalpa), known as black chokeberry, is a shrub native to North America and commonly consumed as juice, wine and jam. Aronia berry contains abundant polyphenols and recently its functionality attracts attention. Therefore, in this study, we examined the effect of Aronia berry extract on TNF-α-induced vascular endothelial inflammation.
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Title: Effect of Aronia melanocarpa (Black Chokeberry) supplementation on the development of obesity in mice fed a high-fat diet
Author(s): Baum, Jamie I.* | Howard, Luke R. | Prior, Ronald L. | Lee, Sun-Ok
Institution(s): Department of Food Science, University of Arkansas, Fayetteville, AR, USA
Publication: Journal of Berry Research
Date: 16 June 2016
Abstract: BACKGROUND: Products derived from black chokeberry are claimed to be beneficial in treating chronic diseases, such as obesity and diabetes. OBJECTIVE: The objective of this study was to determine if supplementation with Aronia melanocarpa (black chokeberry) juice concentrate (AJC) has anti-obesity properties in mice fed obesogenic diets. METHODS: Male C57BL/6J mice (n = 10/dietary treatment) were placed on either a low-fat, high-sucrose (LFHS; 5% fat), LFHS+AJC (1.44 g AJC/kg diet), high-fat (HF; 30% fat), or HF+AJC for 12-weeks. RESULTS: Final body weight was lower in LFHS+AJC compared to LFHS, HF and HF+AJC (∼14, 20% and ∼16%, respectively; P < 0.05). Mice receiving LFHS and LFHS+AJC had significantly higher (P = 0.001) energy intake than HF and HF+AJC. LFHS-fed mice had less (–30%) epididymal fat (p < 0.05) than HF-fed mice, however mice on the LFHS+AJC had less epididymal fat per gram body weight than LFHS controls. There was no effect of diet or AJC on adipose tissue gene expression. There was no difference in plasma insulin, glucose or triglycerides between groups, however there was a positive effect of AJC on adiponectin (P = 0.059). There was also a significant effect of diet (LFHS versus HF) on HOMA-IR (P = 0.004) and HOMA-BCF (P = 0.002). CONCLUSIONS: The results from this study demonstrate that AJC supplementation has the potential to prevent weight gain and markers of obesity. Further research is needed to determine mechanisms of action.
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Title: Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats
Author(s): Stefka Valcheva-Kuzmanova, Atanas Kuzmanov, Vasilena Kuzmanova, Maria Tzaneva
Institution(s): Department of Pharmacology and Clinical Pharmacology and Therapeutics, Medical University Prof. Dr. Paraskev Stoyanov, Varna, Bulgaria; Medical University Prof. Dr. Paraskev Stoyanov, Varna, Bulgaria; Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, Varna, Bulgaria
Publication: Food and Chemical Toxicology
Date: March 2018
Abstract: Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine. Colitis was induced by TNBS in male Wistar rats. After the induction of colitis, AMFJ at three doses (2.5, 5 and 10 mL/kg) and sulfasalazine (400 mg/kg) were administered orally till the 14th experimental day. Severity of colitis was assessed by macroscopic and histopathological criteria. Oxidative stress was evaluated by the concentration of thiobarbituric acid reactive substances (TBARS). TNBS caused severe colonic damage. AMFJ dose-dependently ameliorated TNBS-induced colitis. It improved the macroscopic and microscopic signs of colitis, and prevented the increase of colonic TBARS concentrations. Regarding different indices, the effect of AMFJ was comparable or even higher than that of sulfasalazine. In conclusion, the ameliorative effects of AMFJ in the experimental TNBSinduced colitis might be the result of its potent antioxidant and antiinflammatory properties.
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